![]() He is also a Clinical Adjunct Associate Professor at Monash University. He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. Piperacillin-tazobactam 4.5g Q8hrly, second or third generation cephalosporins, fluroquinolones (ciprofloxacin, moxifloxacin)Īzithromycin or erythromycin, ceftriaxone, ciprofloxacinĬhris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. > resistance to imipenem can develop during treatment (5) fluroquinolones: ciprofloxacin, moxifloxacin mild/ moderate: ceftazidine + co-trimoxazole.co-trimoxazole 10mg/kg of sulphamethoxazole, ciprofloxacin.enterocolitica: fluoroquinolone, co-trimoxazole 10mg/kg of sulphamethoxazole.pestis: streptomycin, gentamycin, doxycycline.fluroquinolones: ciprofloxacin, moxifloxacin.> only 90% coverage with penicillin & amoxicillin > not as much cover with amoxicillin-clavulnate, trimethoprim and co-trimoxazole > amoxicillin and penicillin = waste of time nitrofurantoin 100mg QID PO (5-7mg/kg/day).tobramycin 3-5mg/kg/day in 3 divided doses -> monitor.gentamicin 3-5mg/kg LD -> titrate to trough.> aminoglycosides are good agents (gentamicin, tobramycin, amikacin, streptomycin) co-trimoxazole 10mg/kg of sulphamethoxazole.second or third generation cephalosporin.gonorrhoea: piperacillin-tazobactam 4.5g Q8hrly, ceftriaxone.meningitides: vaccination, penicillin G or ceftriaxone, rifampicin (prophylaxis).Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Munoz-Price L.S., Poirel L.A., Bonomo R., Schwaber M.J., Daikos G.L., Cormican M., Cornaglia G., Garau J., Gniadkowski M., Hayden M.K., et al. Metallo-β-lactamases: The quiet before the storm? Clin. Walsh T.R., Toleman M.A., Poirel L., Nordmann P. Past and present perspectives on β-lactamases. Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis. Tacconelli E., Carrara E., Savoldi A., Harbarth S., Mendelson M., Monnet D.L., Pulcini C., Kahlmeter G., Kluytmans J., Carmeli Y., et al. International study of the prevalence and outcomes of infection in intensive care units. Vincent J.-L., Rello J., Reinhart K., Marshall J.K., Silva E., Anzueto A., Martin C.D., Moreno R., Lipman J., EPIC II Group of Investigators et al. Food and Drug Administration for cUTI (except eravacycline) and most of them for cIAI (eravacycline, ceftazidime/avibactam, ceftolozane/tazobactam, and imipenem/relebactam) and for HAP or VAP (cefiderocol, ceftazidime/avibactam, ceftolozane/tazobactam, and imipenem/relebactam).ĬPE ESBL gram-negative bacteria new antibiotics. At present, all of these new antibiotics are approved by the U.S. All of these new antibiotics are active against ESBL, and almost all of them are active against CPE caused by KPC beta-lactamase, but only some of them are active against CPE due to MBL or OXA beta-lactamases. We reviewed the in vitro activities of these new antibiotics, especially against ESBL and CPE microorganisms, potential side effects, and clinical studies in complicated urinary tract infections (cUTI), intra-abdominal infections (cIAI), and hospital-acquired pneumonia/ventilator-associatedpneumonia (HAP/VAP). Temocillin is an antibiotic that was only approved in Belgium and the UK several decades ago. We aimed to review these antibiotics: plazomicin, eravacycline, temocillin, cefiderocol, ceftazidime/avibactam, ceftolozane/tazobactam, meropenem/vaborbactam, and imipenem/relebactam. Food and Drug Administration (FDA) with predominant activities against Gram-negative bacteria. In the last six years, fortunately, there have been new antibiotics approved by the U.S. When these microorganisms are resistant to third-generation cephalosporines (due to extended-spectrum (ESBL) or AmpC beta-lactamases) or to carbapenems (for example carbapenem producing Enterobacteriales (CPE)), the treatment options become limited. Infections in the ICU are often caused by Gram-negative bacteria.
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